Publications

Find my publications on Google Scholar or Pubmed

2025

Dopaminergic mechanisms of dynamical social specialization in mouse microsocieties

Solié C, Nicolson A, Justo R, Layadi L, Morin B, Batifol C, Reynolds LM, Le Borgne T, Fayad SL, Gulmez A, Allegret-Vautrot J, de Chaumont F, Viollet C, Didienne S, Debray N, Hardelin JP, Girard B, Mourot A, Naudé J, Marti F, Delord B,  Faure P. bioRxiv

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety

Le Borgne T, Nguyen C, Vicq E, Jehl J, Solié C, Guyon G, Daussy L, Gulmez A, Reynolds LM, Mondoloni S, Tolu S,  Pons S, Maskos U, Valjent E, Mourot A, Faure P, Marti F. bioRxiv

2024

Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state

Reynolds LM, Gulmez A, Fayad SL, Rigoni D, Costa Campos R, Nguyen C, Topilko T, Rajot D, Marti F, Heck N, Mourot A, Renier N, Barik J, Faure P. Nature Communications

Individual variations in reward-seeking adaptability emerge among isogenic mice living in a micro-society and predict their response to nicotine 

Fayad SL*, Reynolds LM*, Torquet N, Tolu S, Mondoloni S, Nguyen C, Justo R, Didienne S, Debray N, Viollet C, Brasselet L, Layadi Y, Capaz AM, Topilko T, Renier N, Mourot A, Marti F, Faure P.  PLOS Biology

2023

Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum. 

Caldwell M, Ayo-Jibunoh V, Criollo Mendoza J, Brimblecombe K, Reynolds LM, Zhu XY, Alarcon C, Fiore E, Tomaio J, Phillips G, Mingote S, Flores C, Casaccia P, Liu J, Cragg S, Yetnikoff L. Brain Structure and Function

Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice.

Reynolds LM, Hernandez G, MacGowan D, Popescu C#, Nouel D, Cuesta S, Burke S, Savell KE, Zhao J, Restrepo-Lozano JM, Giroux M, Israel S#, Orsini T, He MY#, Wodzinski M#, Avramescu RG, Pokinko M, Epelbaum JG#, Niu Z, Pantoja Urbán AH, Trudeau LE, Kolb B, Day JJ, Flores C. Nature Communications doi: 10.1038/s41467-023-39665-1

Impact of the gut microbiome on nicotine’s motivational properties and glial cells in the ventral tegmental area

Lakosa A*, Rahimian A*, Tomasi F*, Marti F, Reynolds LM, Tochon L, David V, Danckaert A, Canonne C, Tahraoui S, De Chaumont F, Forget B, Maskos U, Besson M. Neuropsychopharmacology doi: 10.1038/s41386-023-01563-x 

Quantifying dopaminergic innervation in rodents using unbiased stereology.

Reynolds LM, Pantoja-Urbán AH, MacGowan D, Manitt C, Nouel D, Flores C.  In Dopaminergic System Function and Dysfunction: Experimental Approaches. Henny and Funtealba (eds). Humana New York. ISBN: 978-1-0716- 2799-0 doi: 10.1007/978-1-0716-2799-0_2

2022

Social determinants of interindividual variability and vulnerability: the role of dopamine. 

Faure P*, Fayad SL*, Solié C*, Reynolds LM*. Frontiers in Behavioral Neuroscience doi: 10.3389/fnbeh.2022.836343 Invited review to collection: Revisiting Behavioral Variability: What It Reveals About Neural Circuit Structure and Function

2021

Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice. 

Dongelmans M*, Durand-de Cuttoli R*, Nguyen C*, Come M*, Duranté EK, Lemoine D, Britto R, Ahmed Yahia T, Mondoloni S, Didienne S, Bousseyrol E, Hanesse B, Reynolds LM, Torquet N, Dalkara D, Naudé J, Marti F, Mourot A, Faure P. Nature Communications doi: 10.1038/s41467-021- 27268-7

Mesocorticolimbic dopamine pathways across adolescence: diversity in development.

Reynolds LM† and Flores C. Frontiers in Neural Circuits doi: 10.3389/fncir.2021.735625
Invited review to collection: Dopamine Neuron Diversity in Circuits and Diseases

Nicotine inhibits the VTA to Amygdala dopamine pathway to promote anxiety. 

Nguyen C, Mondoloni S, Le Borgne T, Centeno I, Come M, Jehl J, Solié C, Reynolds LM, Durand-de Cuttoli R, Tolu S, Valverde S, Didienne S, Hannesse B, Fiancette JF, Pons S, Maskos U, Deroche-Gamonet V, Dalkara D, Hardelin JP, Mourot A, Marti F*, Faure P*. Neuron doi :10.1016/j.neuron.2021.06.013

Adolescent dopamine development: connecting experience with vulnerability or resilience to psychiatric disease.

Reynolds LM and Flores C  In Diagnosis and Management of Neurodevelopmental Disorders: The Neuroscience of Development :295-304. Martin, Preedy, and Rajendram (eds). Academic Press, ISBN 9780128179888. doi: 10.1016/B978-0-12-817988-8.00026-9

2020

Dopamine Axon Targeting in the Nucleus Accumbens in Adolescence Requires Netrin-1 

Cuesta S, Nouel D, Reynolds LM, Morgunova A, Torres-Berrío A, White A, Hernandez G, Cooper HM, Flores C Frontiers in Cell and Developmental Biology 8:487 doi: 10.3389/fcell.2020.00487

DCC-dependent developmental effects of abused- versus therapeutic-like amphetamine doses in adolescence. 

Cuesta S, Restrepo-Lozano JM, Popescu C#, He S#, Reynolds LM, Israel S#, Hernandez G, Rais R, Slusher BS, Flores C. Addiction Biology 25(4):e12791 doi: 10.1111/adb.12791

2019

Guidance Cues: Linking Drug Use in Adolescence with Addiction Vulnerability.

Reynolds LM, Flores C.  Neuropsychopharmacology doi: 10.1038/s41386-018-0221-7
Invited Submission to special issue: Neuropsychopharmacology Reviews

Early adolescence is a critical period for the maturation of inhibitory behavior .

Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M#, Epelbaum JG#, Lambert LC#, Cossette MP, Arvanitogiannis A, Flores C. Cerebral Cortex 29(9):3676-3686 doi: 10.1093/cercor/bhy247

2018

Non-contingent exposure to amphetamine in adolescence recruits miR-218 to regulate Dcc expression in the VTA. 

Cuesta S, Restrepo-Lozano JM, Silvestrin S, Hoops D, Nouel D, Torres-Berrío A, Reynolds LM, Arvanitiogiannis A, Flores C.  Neuropsychopharmacology, 43(4), 900–911 doi: 10.1038/npp.2017.284

DCC receptors drive prefrontal cortex maturation by determining dopamine axon targeting in adolescence. 

Reynolds LM, Pokinko M, Torres-Berrío A, Cuesta S, Lambert LC#, Wodzinski M#, Del Cid-Pellitero E, Manitt C, Krimpenfort P, Kolb B, Flores C. Biological Psychiatry 83(2): 181–192
doi: 10.1016/j.biopsych.2017.06.009

Dopamine development in the mouse orbital prefrontal cortex is protracted and sensitive to amphetamine in adolescence.

Hoops D, Reynolds LM, Restrepo-Lozano JM, Flores C.  eNeuro doi: 10.1523/ENEURO.0372-17.2017

2017

A non- invasive restraining system for awake mouse imaging.

Madularu D, Mathieu AP, Kumaragamage C, Reynolds LM, Near J, Flores C, Rajah MN. Journal of Neuroscience Methods 287, 53–57. doi: 10.1016/j.jneumeth.2017.06.008

Advances in understanding and treating mental illness: Proceedings of the 40th Canadian College of Neuropsychopharmacology Annual Meeting Symposia.

Normandeau CP*, Naumova D*, Thompson SL*, Ebrahimzadeh M*, Liu YQ*, Reynolds L*, Ren H-Y, Hawken ER, Dumont EC. Journal of Psychiatry and Neuroscience Sep;42(5):353-358 doi: 10.1503.jpn/170120

2016

dcc haploinsufficiency results in blunted sensitivity to cocaine enhancement of reward seeking. 

Reynolds LM, Gifuni AJ, McCrea ET#, Shizgal P, Flores C. Behavioural Brain Research 298A: 27-31 doi: 10.1016/j.bbr.2015.05.020
Invited Submission to Special Issue: Developmental Regulation of Memory in Anxiety and Addiction

2015

Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a dcc-dependent manner.

 Reynolds LM, Makowski CS#, Yogendran SV#, Kiessling S, Cermakian N, Flores C. Neuropsychopharmacology Mar;13(40):1101-12 doi: 10.1038/npp.2014.287

2014

Neural basis of benzodiazepine reward: Requirement for α2-containing GABAA receptors in the nucleus accumbens.

Engin E, Bakhurin KI, Smith KS, Hines RM, Reynolds LM, Tang W, Sprengel R, Moss SJ, Rudolph U. Neuropsychopharmacology Jul;39(8):1805-15. doi: 10.1038/npp.2014.41

2012

Differential roles of GABAA receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward.

Reynolds LM*, Engin E*, Tantillo G, Lau H, Muschamp JW, Carlezon WA, Rudolph U. (2012) Neuropsychopharmacology Oct;37(11):2531-40. doi: 10.1038/npp.2012.115